LubriSyn HA+ and You
LubriSyn HA+ is an oral, liquid form of high molecular weight hyaluronan (HA). It is also 100% vegan and gluten free.
Powdered or pill forms of HA must go through the entire digestive tract, breaking down the HA molecule and taking far longer for any remaining available HA to be absorbed.
Unlike other forms of liquid HA made from animal sources (e.g., rooster combs), LubriSyn HA+ is extracted from a microbial source. This method keeps LubriSyn HA+ free from protein contamination that can cause other HA products to break down.
Because any form of HA that is introduced to the body from an external source only remains in the body for 36 hours, it is important to take LubriSyn HA+ every day. Begin with one tablespoon daily for the first 14 days, and then back down to two teaspoons a day thereafter.
The only active ingredient in LubriSyn HA+ is Hyaluronic Acid.
LubriSyn HA+ has a pleasant, slightly sweet taste. Our products are also 100% vegan.
LubriSyn HA+ is simply HA (hyaluronan), and will not interact with any drug you may be taking. It is also low in sodium, making it safe for those who have high blood pressure.
LubriSyn HA+ and Your Pet
With over 200 moveable or semi-movable joints in their bodies, dogs must have joints that move comfortably and freely. LubriSyn HA+ provides the missing piece in joint health management: synovial fluid support. No other method provides the oral, natural hyaluronic acid (HA) that LubriSyn HA+ Pet & Equine offers to cushion and lubricate the joint on a daily basis.
LubriSyn HA+ is an all-natural, oral, liquid form of Hyaluronic Acid. The purified, high molecular weight hyaluronan in LubriSyn HA+ is extracted from a microbial source. Other oral HA products are made from rooster combs or chicken cartilage. The microbial biofermentation results in a high molecular weight HA, and keeps it free from proteins, dermatan, chondroitin sulfate and other glycosaminoglycan contamination that may be found in other HA products.
Normal, healthy synovial fluid contains hyaluronan (HA) with a molecular weight of two to three million Daltons (MDa). Smaller molecular weight HA is not the same. As the molecular weight decreases, fluid viscosity decreases. Based on studies of intra-articular injections of HA in humans, the higher molecular weight HA molecules can relieve pain. HA at the higher molecular weight that matches native HA is associated with the beneficial roles that we expect in a healthy joint. Bigger is better!
Supplemental hyaluronan can increase synovial fluid viscosity. LubriSyn HA+ is used to provide joint health support during treatment for osteoarthritis, osteochondrosis, rapid growth, exercise and the rigors of normal wear and tear. Elite AKC Obedience and Agility trainers are using LubriSyn HA+ to support their canine partners during competition. LubriSyn HA+ helps increase synovial fluid viscosity as an oral supplement.
LubriSyn HA+ Pet & Equine is an daily oral hyaluronan joint supplement. Adequan Canine is an injectable drug given by veterinarians to dogs to help improve joint function. Adequan is a polysulfated glycosaminoglycan that can increase production of joint hyaluronan. It is recommended by Novartis Animal Health to be given twice a week for four weeks; each injection has a duration of effect lasting about three days. (Novartis 2005) Pets can still be given LubriSyn HA+ Pet & Equine while receiving Adequan.
Our safety studies have shown that even at five times the recommended dose for 60 days, there were no adverse effects. Copies of our safety study analysis are available to you.
The recommended daily oral dose for dogs is one teaspoon (5 ml) for dogs up to 30 pounds body weight. For dogs between 30 and 60 pounds, we suggest One and one-half teaspoons daily. For dogs between 60 and 100 pounds, two teaspoons. The amount may be doubled for hard-working dogs.
No. LubriSyn HA+ Pet & Equine is beneficial to the joint fluid. Cosequin is composed primarily of glucosamine and chondroitin sulfate and works on cartilage. (NutraMax Laboratories, Inc. 2005)
LubriSyn HA+ Pet & Equine is basically odorless and has a lightly sweet taste that most dogs love.
Most animals will show an improvement in seven to fourteen days.
Studies of high molecular weight hyaluronan show that it begins to appear in tissues outside the intestinal tract in 30 minutes, and peaks between four and six hours post ingestion. As a daily supplement, LubriSyn HA+ Pet & Equine provides a continual supply of hyaluronan to support the rapid turnover of synovial fluid hyaluronan.
Yes. As with most liquid nutritional supplements, extreme hot or cold temperatures can cause breakdown, rendering the product ineffective. We recommend storing LubriSyn in a temperature range between 40 and 90 degrees Fahrenheit; It is advised that LubriSyn HA+ not be frozen. LubriSyn is best used by the date indicated on the bottle: 18 months is the recommended shelf life.
No. Hyaluronan is a naturally occurring substance found in the joints, skin and other tissues of all mammals. LubriSyn HA+ Pet & Equine is made from a microbial source of hyaluronan along with a very small amount of sodium benzoate and potassium sorbate as protectants.
These are three different names for the same compound.
LubriSyn HA+ and Your Horse
LubriSyn HA+ is an oral, liquid form of hyaluronic acid (HA). HA is the main constituent of joint fluid. LubriSyn HA+ maintains healthy joints through daily oral use by improving the quality of the synovial fluid that cushions and lubricates your horse’s joints.
Your horse’s joint fluid deteriorates with age and exercise. In fact, the more you work your horse, the faster joint fluid degenerates and the more likely bone-on-bone inflammation will occur. LubriSyn HA+ replenishes and restores joint fluid, without the stress, pain and expense of regularly scheduled joint injections. LubriSyn HA+ also enhances joint health when you do choose to use injectables.
Both products are drugs approved by the Food and Drug Administration to treat arthritis or joint inflammation and are administered by injection. Legend is hyaluronic acid formulated for intravenous or intramuscular use. Adequan is polysulfated chondroitin sulfate also formulated for intramuscular use. Both products result in a rise in blood concentration after administration followed by a return to baseline levels within several hours unless the drug is re-administered (Popot et al., 2004).
No. Cosequin is mainly made up of glucosamine and chondroitin sulfate. Cosequin works on the cartilage while LubriSyn HA+ is beneficial to the joint fluid. It is important to know that cartilage heals best when the joint fluid that surrounds it is healthy and viscous. LubriSyn HA+ provides the best possible joint fluid environment for healthy cartilage.
The liquid form is more readily and quickly absorbed in the tissues of your horse’s mouth and throat, providing joint support in as little as 7 to 14 days. Powdered or pill forms of HA must go through the entire equine digestive tract, breaking down the HA molecule and taking far longer for any remaining available HA to get to the joint fluid.
Unlike other forms of liquid HA made from animal sources (e.g., rooster combs), LubriSyn HA+ is extracted from a microbial source. This method keeps LubriSyn HA+ free from protein contamination that can cause other HA products to break down and lose their effectiveness.
While many people begin treating their horses with LubriSyn HA+ because they are having mobility challenges or joint pain, LubriSyn HA+ is an excellent preventative supplement. Top thoroughbred athletes benefit today from receiving LubriSyn HA+ on a daily basis from the time they are weanlings, throughout their careers. Elite thoroughbred trainers like Todd Pletcher, Tony Dutrow, and Jerry Hollendorfer use LubriSyn HA+ on every horse in their barns.
Because any form of HA that is introduced to the body from an external source only remains in the body for 36 hours, it is important to give your horse LubriSyn HA+ every day. We recommend that you start with a “loading” dose for one week of 30 ml or one ounce. Then you can drop it to the “maintenance” dose of 15 ml or one-half (1/2) ounce. The gallon size comes with a pump that can be placed directly in the container. Each “squirt” is a measured 15 ml dose. The other option for the gallon is the dosing gun. It also fits right on the gallon and administers a measured dose directly into your horse’s mouth.
The only active ingredient in LubriSyn HA+ is HA. Glucosamine and chondroitin target cartilage, not joint fluid.
You won’t find LubriSyn HA+ at the bottom of your horse’s feed tub, as you may with many powdered supplements. Many people simply top-dress their horse’s feed. Others feel more comfortable using the dosing gun placed directly in the animal’s mouth.
There is no exact time frame. Most horses observed have improved noticeably within seven to 14 days. Results vary depending on severity of the joint health problems and the dose of LubriSyn HA+.
“Will the Real HA Please Stand Up?” is a scholarly article that was published in the 2004 edition of The Journal of Applied Nutrition. This article affirms that the high-molecular weight formula of LubriSyn HA+, extracted from a microbial source, is the most effective form of HA available on the market. We also have an independent safety study available for review at www.LubriSynHA.com
Yes. As with most liquid nutritional supplements, extreme hot or cold temperatures can cause breakdown, rendering the product ineffective. We recommend storing LubriSyn HA+ in a temperature range between 40 and 90 degrees Fahrenheit. You may not freeze or overheat LubriSyn HA+!
No. HA is a naturally-occurring substance in every mammal’s body, and will not show up in a post-competition test. However, if you are competing under “zero supplement” regulations (e.g., FEI), the horse will not suffer any ill effects of LubriSyn HA+ withdrawal during the few days of competition.
References
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NutraMax Laboratories, Inc. 2005. http://www.nutramaxlabs.com/Brochures/Cosequin Dog Brochure.pdf (accessed Feb 22, 2007).
Ohkawara, Y, G Tamura, T Iwasaki, A Tanaka, T Kikuchi, and K Shirato. “Activation and transforming growth factor-beta production in eosinophils by hyaluronan.” Am J Respir Cell Mol Biol 23, no. 4 (Oct 2000): 444-451.
Schauss, AG, LG Balogh, AG Polyak, RG Kiraly, and i GG Janok. “Absorption, distribution and excretion of 99mtechnetium labeled hyaluronan after single oral doses in rats and beagle dogs.” FASEB j 18, no. 4 (2004): A150-151.
Takahashi, T, et al. “A decreae in the molecular weight of hyaluronic acid in synovial fluid from patients with temporomandibular disorders.” J Oral Pathol Med 33, no. 4 (Apr 2004): 224-229.
Yeung, RW, RL Chow, Samman N, and K Chiu. “Short-term therapeutic outcome of intra-articular high molecular weight hyaluronic acid injection for non-reducing disc displacement of the temporomandibular joint.” Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102, no. 4 (Oct 2006): 453-461.
